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According to a press release dated 3 March 2017, on 10 March 2017 the Central Bank of Uzbekistan Republic introduced a new 10,000-som note (B214), double the value of the previous largest denomination in the country, yet still worth only US$2.95 at present exchange rates.
Courtesy of Hartmut Fraunhoffer (Banknote-Online) and Vadim Tislenko.