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In 2011 it was reported that the Banco Central del Paraguay was contemplating issuing polymer notes. According to this post on UltimaHora.com, the 5,000-guarani (US$1.10) note was issued as a polymer note on 14 January 2013. The note is dated 2011, and has reportedly been printed without imprint by Canadian Bank Note Company.
Courtesy of Mohammad Raihan and Thomas Krause.